Synthroid is FDA pregnancy category A - it is definitely secure for breastfeeding Synthroid or Levothyroxine in its generic form, is a a commonly used medication to treat Hypothyroidism, an underactive thyroid. provide 680 mg of elemental strontium as this is the dosage shown in the research studies to be effective. My question has to do with breast cancer. Strontium ranelate was used in these trials. Ranelic acid can provoke not only nausea and diarrhea, but venous thromboembolism, liver damage and a potentially deadly autoimmune response that initially manifests as a rash and may quickly evolve to DRESS, SJS and/or TENS. And stay gloriously well, In additional to calcium-containing foods, foods that contain alginate (found in kelp) lower strontium absorption, and so do certain medications, including quinolone antibiotics, and medications that contain aluminum hydroxide or magnesium hydroxide. I now know that the strontium citrate was not likely too well absorbed, but are there any negative side effects of taking strontium citrate and eating a calcium rich meal? Raw vegetables This one is specially for those who are diet conscious and believe that salads are great anytime of the day. 2004 Jun-Jul;20(6-7):631-3. Please dont apologize for asking such interesting questions, especially since the answers to them could have very significant practical relevance for human health. The form of strontium you should consider taking is strontium citrate NOT strontium ranelatethis form has caused many adverse effects, which I have written about at length both in my book Your Bones, 2nd edition and on AlgaeCals blog. Strontium is eliminated by our kidneys, so it may accumulate in patients with chronic kidney disease, as their kidneys ability to filter the blood is compromised. A comparison of adverse event and fracture efficacy data for strontium ranelate in regulatory documents and the publication record. Hi Shaine, What you are now doing sounds just fine, although a number of other nutrients are required for optimal bone health you should also be getting adequate vitamin D3, vitamin K2, boron, magnesium and vitamin C plus a wide range of trace minerals. In the U.S., Canada and Europe, the typical diet contains 24 mg strontium/day. Hope this helps and if you have any questions, dont hesitate to reach out to our Bone Health Consultants at 1-800-820-0184 . Other studies suggest that after midlife, in men as well as women, there is an age-related yearly loss of bone of 1%, which, for women, accelerates to 2% for up to 14 years around the age of menopause (which typically occurs around age 52). I should have been Our active intestinal absorption of strontium is vitamin D-dependent and decreases with aging, and with consumption of phosphate additives as well as calcium. I am now 55 years old. You may be surprised to see how much calcium your diet is providing when you add it up. Strontium ranelate given to intact rats at doses up to 900 mg/kg/day increases bone resistance, cortical and trabecular bone volume, micro-architecture, bone mass, and total ALP activity, thus indicating a bone-forming activity and an improvement of overall bone tissue quality. Thankful for reply before I order. I mightve read it too fast. It is generally agreed that bone strength depends on the bone matrix volume and the microarchitectural distribution of this volume, while the degree of mineralization of bone tissue is almost never mentioned as a determinant of bone strength. In regards to your question about strontium being taken as a single dose in the COMB study, this is not unusual. Dr. Grout does offer BHRT. Bone. Strength/stability of apatite crystals Apatite, which is composed primarily of calcium + phosphate, is the basic mineral component used in our bones and teeth. Three women in the exercise group experienced musculoskeletal problems that required minor modifications in their training regimen. A creatinine clearance rate of 90 or greater indicates normal healthy kidney function. AlgaeCal has 2 in vitro and 2 human clinical trials proving its effectiveness. Strontium ranelate comes with risks of unwanted side effects. 10. The common myth is that strontium supplementation results in larger concentrations of strontium in your bones. Very glad to hear you are doing many of the things I noted that are essential for healthy bones. I take Strontium Bone Maker every day along with my New Chapter Bone Strength Take Care Calcium supplement. From Laras Comment at bottom of: Strontium Side Effects are Overblown Get the Facts: Strontium is almost twice as large as calcium, and its larger size does affect DXA readings. Definitely a win on all fronts! What do you make of this 2012 study linking strontium to increased incidence of breast cancer? Equating them is like suggesting sodium chloride (table salt) and sodium bicarbonate (baking powder) are the same. Combined with X-ray diffraction and secondary Raman spectroscopic images, it was demonstrated that strontium was dose-dependently taken up by the bone mineral and heterogeneously distributed in compact and cancellous bone, with a higher amount in newly formed bone tissue than in old bone tissue. The other night I contacted the manufacturer of my strontium and inquired as to if the supplement was better absorbed on an empty stomach or with food. In contrast, no correlation was found for the expressions of metabolizing enzymes between rat and human intestine, which indicates the difference in drug metabolism and oral bioavailability in two species. AlgaeCal Plus is giving you 350 mg, an amount that perfectly balances the 720 mg of calcium it provides. Wnt signaling: Wnt signaling is involved in osteoblast production & activity; strontium triggers Wnt signaling. Eventually, I expect we will be able to get our full genetic template. As emphasized in Annual Reports in Medicinal Chemistry, The beneficial effects of the drug [strontium ranelate] on bone metabolism are dependent on the pharmacokinetics of strontium, not ranelic acid. Annual Reports in Medicinal Chemistry, volume 40, 2005, ed. My COPD isnt an issue any longer, since Dec. 09. She had test results from a strontium/serum/plasma/urine test that far exceeded the normal ranges. Were always happy to share information that helps guide our community on their bone health journey. I take about 350 mg of magnesium, and 3 tablets of ALTA silica a day, and Vit D3 is 3000, Omega 3 oil. Ive seen this mentioned in comments on several websites. Normal results from this test range from 10.0 45.0 ng/ml. If you are consuming a Mediterranean-style diet rich in organically grown vegetables (esp leafy greens, whole grains, nuts [eg Brazil nuts are an excellent source of selenium so good that you dont want to consume more than 2 Brazil nuts a day]), then this combined with AlgaeCal Plus will be providing you with a good supply of trace minerals. As already mentioned, we know that lower doses are still effective just not as effective, so taking the lower doses would be advisable after the temporary period of higher doses. Im not sure where I should look for a response. Essential Elements Bone Boost Bone Health Supplement - Calcium, Vitamin D3, K2, Cissus Quadrangularis for Bone Strength - 90 Capsules (30 Day Supply) Features : Powerful Bone Health Supplement - Bone boost contains an expert-designed formula aimed at complete bone health support. OPG is a decoy for RANKL and binds to RANK, decreasing osteoclast production; strontium increases OPG production. The key point here is that when Strontium Boost is used and the possibility of overestimation is factored in the result is still an increase in BMD averaging 0.91 to 0.95% annually. So Im here to set the record straight, Having reviewed the published research on the different forms of strontium: natural strontium, the strontium ranelate drug, along with the radioactive form of strontium, I can confidently assure you that the natural form of strontium, strontium citrate, is a safe and effective bone health supporter. Here is a link to one of these articles:http://www.lmreview.com/articles/view/vitamin-a-tolerance-extends-longevity/ Japanese Natto (fermented soybeans) has extremely high concentrations of vitamin K2 and packets of frozen natto are available at low cost from Asian food shops. I dont want to do something that would cause other problems. Radioactive strontium is formed in nuclear reactors or during the explosion of nuclear weapons. Both IGF-I and Runx2 levels were positively associated with the bone mineral apposition rate (MAR). is really stellar. M. Hi Marilyn, (So it could have been di-Sr, a mixture or something else.) In other words, 3 capsules give you 1550 mg of citrate AND 680 mg of strontium. Description. In Laura Pizzornos blog , she refers to the excretion of ranelic acid , and questions the non excreted portion. For most people, 3 hours or even 2 hours will be sufficient. In most people, strontiums effects on glutamate secretion promote relaxation and deeper, more restful sleep, but in some people, these effects cause next day grogginess or nap attacks. You could try taking your Strontium mid-day to see if this helps. I do have Hashimotos and have been on a compounded T3 for over 20 years. I always thought it just added to the calcium and helped strengthen. Strontium both lowers osteoclast production and activity and increases osteoblast production and activity. Hi Lara, Thanks for your reply. Hi Lara, Note that the COMB study was conducted by Dr. GenUIs (not Genius)I have contacted his office regarding the type of exercise that was used by patients in the study and was surprised to learn that he recommends jumping, running, or jogging (exercises that are typically contraindicated for osteoporotic patients), working up to 300 repetitions. "Know that, ma'am." "Then why are you" "Three ways to do this, ma'am." Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. I started out taking just 1 capsule not because I wanted to take less than 680 mg of strontium but b/c I did not carefully read the label. I may drop down to 1/4 the dosage though. There were a series of studies run as part of the Ryerson and McMaster University Strontium in Bone Research Study in Toronto, Canada, that confirm this, so I am giving you links to several of these papers here: https://www.ncbi.nlm.nih.gov/pubmed/22549020 https://www.ncbi.nlm.nih.gov/pubmed/26910208 https://www.ncbi.nlm.nih.gov/pubmed/24434614. . Their reply was with food was preferable. You simply must experiment and see what works best for you. Last summer (July 2011), I switched to AlgaeCal Plus as my source of supplemental calcium and to Strontium Boost for my strontium supplement. Heres a quote from this paper summarizing the results of several studies discussing this: If you get your medications from a reliable pharmacy, ask your pharmacist to double-check for you. Thanks for the info on Vitamin D. Thats interesting that it was advised to only state 100%, but in some ways isnt surprising. I very much hope this information will be of help. I think thats too much along with the 720 from AlgaeCal but dont wanr to miss out on the other vitamins & minerals if I stop taking the multivitamin. Also still taking the Metagenics Ostera, as it is supposed to help if you take steroids. Doctors in our part of the world usually wont talk and discuss the issues much with their patients or bother to reply to their questions even after massive fee that they charge. I live alone and lost my family. I have had open heart surgery and I have a titanium mitral valve and a pacemaker. (1977) Toxicology V.7 p. 11-21. PMID: 11336927 again discusses that strontium primarily deposits in newly forming trabecular bone. And neither study shows strontium depositing primarily into cortical bone. Hey Tyler, In fact, 99% of the total amount of strontium in the body is found in bone, a trait it shares with calcium. If this happens on an empty stomach with no food present to disperse the highly concentrated vitamins and minerals, the result can be nausea. The 2230 mg amount is the milligrams of strontium plus citrate. I live in Arizona, but lungs keep me inside mostly as air here is dry and very dusty. I read the article by Meunier that he cited, but it was evident that said article supported 680 mg not 170 mg to be the most effective. Hope this helps. I definitely understand that you wouldnt want to lose any hair! In conclusion, the different studies performed on bone samples from monkeys and humans treated with various doses of SR showed that Sr was heterogeneously distributed between new and old bone but in a dose-dependent manner without alteration of the crystal characteristics and the degree of mineralization of bone tissue, even after long-term administration of often high doses of SR (the highest therapeutic dose used in humans is 4-fold lower than the lowest experimental dose administered to monkeys). Why is it so much more effective? Thanks for reaching out, Sharon! Be sure to take it when you are NOT also taking calcium or consuming calcium-rich foods. Thanks for sharing and we hope you enjoy some of our other blog articles ? I have family sisters with ckd. Quick follow-up questions. It was very informative. Where did you read that estrogens might decrease strontium metabolism? I was attempting to simplify but see that just increases potential for confusion. The most current research looking into the use of high velocity progressive resistance training is just underway and will, hopefully, give us more insight into the best exercise protocols to prevent bone loss and rebuild osteopenic, osteoporotic bone. However, osteomalacia is also frequently seen in end-stage renal failure patients who are not yet on dialysis and who have normal bone strontium levels. A member of the American Medical Writers Association for more than 25 years, Lara publishes and reviews articles covering breaking research on bone health in Integrative Medicine: A Clinicians Journal. I do not know her personally, but she is a member of the Institute for Functional Medicine a very good sign, the doctors involved with the IFM are both better informed and more open to integrative medicine. AlgaeCal was also found to significantly reduce oxidative stress in the osteoblasts after just 24 hours. No adverse effects. All three AlgaeCal Plans tested produced increases in BMD a marked improvement over just slowing the rate of age-related bone loss. If you follow the dietary recommendations in Your Bones, you will lower your blood pressure along with your risks for virtually all chronic degenerative diseases, and build healthy bones along with overall good health. I had a normal DEXA for 2017 and 2019. In Table 1 from this paper, the researchers looked at the increases in BMD reported with use of Strontium ranelate in the STRATOS and SOTI trials. The reasons for this are that failing kidneys lose their ability to: So, if you are on dialysis or have end stage of kidney failure, ask your doctor for advice on whether to proceed with strontium supplementation. Because strontium is almost twice as large as calcium, even this tiny number of strontium-for-calcium ions exchanged in your bones can impact DXA readings. If you are producing higher amounts of the pro-carcinogenic forms of estrogen, dietary changes, such as consuming more cruciferous vegetables and fewer pro-inflammatory processed foods, and some very safe herbal supplements can lower your production of potentially harmful estrogens. [emailprotected]. Natural strontium salts are safe (at reasonable dosages, of course) and highly beneficial. Please clear this up and let us know whether taking the two minerals separately just allows both to remineralize bones, or causes strontium to replace the calcium in bones. I am not being paid to respond to questions here on this blog. 196 And a recent meta-analysis of 12 well-controlled trials comparing hydroxyapatite to calcium carbonate to prevent bone loss found No worries! Or is there some issue with her ability to absorb calcium as well? Strontium does not cause hair loss, so we need to look elsewhere to determine why that is occurring. Saying that those taking strontium ranelate had a relative risk for VTE of 1.4 compared to placebo means that strontium ranelate increased risk for VTE by 40%. https://www.ncbi.nlm.nih.gov/pubmed/26516910 Hope this helps, Lara, I have recently been diagnosed with coronary artery disease AND low bone mass. Strontium has nearly twice the atomic weight of calcium. Abstract I really want to underscore here the fact that the strontiums beneficial effects on our bones are NOT due to its replacing calcium in our bones! Strontium increases our absorption of calcium yes, calcium! (2) The first study cited by Genuis et al. If you are concerned about this, have either the MVL test or the DUTCH test run to check how your estrogens are being metabolized. 223-224. Hi Connie, Should I introduce the strontium gradually, building up from one pill to two to three over a period of time or should I take one pill three times a day? The key issue regarding the safety of natural forms of strontium is calcium intake, which to err on the side of safety, should be at least double that of the amount of strontium consumed. I just came across this thread and have a question. Strontium ranelate the prescription drug form of strontium is associated with a very serious rash-like syndrome called DRESS syndrome, so if you were taking that, I would be telling you to head to the emergency room right away!. Her range was almost 2,000 ng/ml ( which she indicated was over 4,000 higher than normal). I found your product and started taking it this week, however when I take the Strontium at night, I get this weird pain in my right thumb, where the thumb joins the hand and I cant use it to lift anything it is very weird. Because doctors do not tell you the truth when it comes to improving your bone density. I want to underscore here that this is a competition that calcium always wins, which explains why: Ok, now that you see the differences in the 3 main types of strontium, lets dig into the common misconceptions surrounding this valuable mineral. Once you are in osteopenic range, you can cut your dose of strontium in half. I have corresponded with a number of leading researchers. The information on Algaecal sounds good, but I would like to hear a recommendation fom someone besides the people selling the product. We hope this helps! For this, you can try two things (1) ensure you are eating plenty of magnesium-rich foods (if you have a copy of Your Bones, I provide a table listing them and showing how much magnesium is in a typical serving of each food, p. 226. Please do not be overly concerned about having a calcium at high end of normal remember, you are still within the normal range. Im not familiar with Quick Silver; what labs do they run? While the baseline levels of 0.38 0.05 and 0.39 0.10 for the finger and ankle, respectively, were on par with those previously reported in Caucasians among twenty-two healthy non-supplementing strontium individuals by our group, an increase began to be seen after 24 hrs of 0.62 0.14 and 0.45 0.12 for the finger and ankle, respectively. This confuses me, because I thought Strontium (from Strontium Citrate) 680 mg literally means there are 680 mg of strontium (not strontium citrate) in 2 capsules. Interesting that my calcium was high and I have never taken calcium supplements until quite recently. Hi Lara, I am recently diagnosed with Oestopenea, I live in a part of world with poor health facilities and women health are completely neglected. Any suggestions on when to take? In fact, 99% of the total amount of strontium in the body is found in bone, a trait it shares with calcium. Radioactive strontium isotopes (85Sr and 89 Sr) are also used as delivery agents for chemotherapy drugs and for diagnostic purposes in kinetic studies. Please advise soonest, if it is okay for me to take the Algae Plus without the strontium as I am suffering of thrombocytopenia as well. I do plan on continuing the algae cal plus but question if I need 4 capsules each day or if I can cut the dosage. http://ukpmc.ac.uk/theses/ETH/2476. Pors Nielsen S. The biological role of strontium. Thanks for sharing this research! To help lower your blood pressure (and build healthy bones), eat lots of mineral (potassium, magnesium, calcium)-rich green leafy vegetables and avoid the unrefrigerated stuff (I refuse to call this food) in boxes and cans in the aisles of your grocery store the processed food-like items. Hi, I have been taking calcium, calcium rich foods and exercising to keep my bones strong, but my bone density test still show low bone density in my right hip. Vitamin K2 is fat-soluble its in the fat, so when the fat is removed, so is the K2. Best Strontium Citrate. Joe took a look to see who is in Arizona near Phoenix, and discovered that one of the contributors to the Textbook of Natural Medicine, Dr. Tom Kruzell, ND, is in Scottsdale! Originally, the labels were made just as you suggested, but for some legal reason, they were told 100% is maximum that should be stated for vitamin D. Also as I am sure you know, some experts are still saying 600-800 IU of vitamin D is the recommended amount despite years of research and literally hundreds of studies now showing this is not the case. I am NOT paid by AlgaeCal to promote its products. We recommend speaking with your doctor to see if Strontium Boost is right for you. However, as I hope I keep repeating, each of us is UNIQUE. Thanks again for catching my misspelling of Dr. Genuis name and for your really great questions, Lara, Hi Lara, And your BMD score will also be impacted if the technician running your scan does not place your body exactly as it was placed on your prior scan. I know it works, Lara, Lara: Take it with water, and don't eat or drink anything else for at least 30 minutes afterward. LIPUS stimulation on metastatic bone tumors induces differentiation of osteoblasts without proliferation of tumor cells. Maybe animal studies? What the research shows is that strontium, in addition to its numerous beneficial effects that boost osteoblast and slow osteoclast activity, also indirectly inhibits resorption of the calcified bone matrix by stabilizing hydroxyapatite crystals. If you have low bone density, you will receive the most benefit from a 680 milligram per day dose of strontium citrate. You are a brave and intelligent woman! ERBB2 encodes a protein called HER2 (from human epidermal growth factor receptor 2) or you may see it referred to as HER2/neu. HER2 is a member of a family of human epidermal growth factor receptors (the HER/EGFR/ERBB family). I wore a Holter monitor for 24 hours but the doc didnt find an issues. I dont know how much strontium is in Drs Best (am currently in Toronto airport with just a few minutes before my connecting flight to Washington DC, so no time to look), but most supplements providing strontium citrate (which is what you want you do NOT want the patented drug form, strontium ranelate!) Im now almost 70; the maximal human lifespan is currently thought to be ~120 years and my son, who is just graduating from medical school this May (with honors), has had not time to even think about a relationship, much less marriage and children. What about iron and magnesium regarding strontium? I suggest you ask the folks making these claims for references in the medical journals in which research has been published confirming them, and if they cannot supply you with any, do not give them any credence. AlgaeCal Plus provides the key nutrients our bones must have to maintain themselves, regardless of our age, and in amounts shown in the research to be sufficient for most people. 350, 459-468. The SR SPC(23)gives a value for Fspineof 50%. Please feel free to contact our Bone Health Consultants 7 days a week at 1-800-820-0184 (USA & Canada, toll-free) or email [emailprotected] for more information and personalized support! What is your digestion like, normally? Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosisa 2-year randomized placebo controlled trial. My favorite is plain, organic, whole milk Greek yogurt we have a dish full every night along with some berries or other fruit and a handful of nuts or gluten-free granola for dessert. I am on a low salt diet to control my blood pressure. Are you familiar with this brand? Lara. This is what I do for myself. I do much better with starchy whole vegetables like potatoes, yams, corn, beets, winter squash. [Breast Cancer Patient with Bone Metastases Who Was Able to Return Home without Using Opioids after Administration of Strontium-89 Chloride]. . Just prefer not to take anything that may have side effects. She is in Scottsdale, heres a link to her website. I was cautious about the calcium because of Mr. Barr, and was even more cautious when I found out I was in the higher range with no supplementation. Need more info on YOU and and why you are restricting soy and dairy as well as gluten. Epub 2013 Jul 24. BMC Musculoskelet Disord. As a medical editor/writer, I typically spend 3-4 hours every day scanning the research and bone health is my special interest, so thats how I learned about AlgaeCal. Besides. The other night I contacted the manufacturer of my strontium and inquired as to if the supplement was better absorbed on an empty stomach or with food. . Lastly, and to me the most important point, is that strontium does not improve bone health, resistance to fracture, by increasing BMD. Indeed, strontium only overestimates BMD by an average of 10%.5 But now, after my in-depth review of the current research on strontium which involved reading more than 70 recently published papers in the peer-reviewed medical literature I am convinced that strontium citrate has so much to offer that will help ensure my bones remain healthy that Ive begun supplementing with Strontium Boost again! We would not expect accelerated bone loss after stopping strontium, and in fact, we suggest discontinuing Strontium Boost after a DEXA reading shows bone density within the normal, healthy range. I cannot know your financial situation, but nothing is as important as your health. Especially thanks for the links to research. Citrate is a favorite food of unfriendly bacteria. (Here is the reference for this study: Ma B, Zhang Q, Wang G, et al. Ranelic acid is the synthetic compound used to create the unnatural strontium salt, strontium ranelate. We now have evidence that the degree of mineralization of bone tissue strongly influences not only the mechanical resistance of bones but also the bone mineral density.

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